Journal article
Relaxin-3 mRNA levels in nucleus incertus correlate with alcohol and sucrose intake in rats
PJ Ryan, EV Krstew, M Sarwar, AL Gundlach, AJ Lawrence
Drug and Alcohol Dependence | ELSEVIER IRELAND LTD | Published : 2014
Abstract
Background: Chronic alcohol intake produces multiple neuroadaptive changes, including up- and down-regulation of neuropeptides and receptors. There are widespread projections of relaxin-3 containing neurons to, and abundant relaxin family peptide 3 receptor (RXFP3) expression within, brain regions involved in modulating alcohol intake. Recently we demonstrated the involvement of relaxin-3/RXFP3 signalling in alcohol-seeking in rats; therefore in this study we examined whether relaxin-3 and/or RXFP3 expression were altered by chronic alcohol intake in alcohol-preferring iP rats. Methods: Expression of relaxin-3 mRNA in the hindbrain nucleus incertus and RXFP3 radioligand binding levels in dis..
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Funding Acknowledgements
This research was supported in part by project grants 508976, 509246 and 1021227 from the National Health and Medical Research Council of Australia, of which ALG and AJL are Research Fellows. We gratefully acknowledge financial support from the Besen Family and Pratt Foundations and the Victorian Government's Operational Infrastructure Support Program. PJR was supported by an Australian Postgraduate Award and a Dowd Foundation Scholarship; MS was supported by an Australian Research Council Postgraduate Scholarship.